The core business of the Institute is R&D for the generation of new knowledge and technology innovation. MGI conducted research projects being funded by ministries and also some collaboration with local and international universities or research organisations.
Genomics & Molecular Biology Initiatives Programme (9th MP)
This programme is focusing on capacity building as the execution of the 1st Phase of National Biotechnology Policy.
Structural Genomics of Burkholderia pseudomallei Essential Genes and Transcription Factors
Comparative Genomics of Eimeria Species
Asian Sea Bass Genomics for Genetic Improvement
Development of Novel Technology for Accurate Function Prediction Based on Protein 3D Structure and Molecular Interaction Information
Identification of Novel Molecular Signatures as Potential Drug Targets for Diseases in Fisheries and Livestock
Consolidated Bioprocessing of Oil Palm Lignocellulosic BioMass: Molecular and Bioprocessing Approaches
Novel Systems Biology Approach Towards Elucidation of Biosynthesis Networks of Secondary Metabolites
Genome and Functional Analyses of Newcastle Disease Virus
Biosynthesis of Secondary Metabolites: Engineering the biosynthetic pathway for over-production of flavonoids and chalcones in plants and microbes cell culture
Development of Excretory Expression System for Enzyme / Protein Production in Bacteria and Fungi
Development of Selected Industrial Enzymes and Protein from Psychrophiles
Development of Yeast Systems for Producing Industrially Important Enzymes
Building of Genomics-led Green Chemistry for Industrial Biotechnology
Dengue Virus Genome: Dynamic s of Dengue Viruses Antigenic Epitopes In Recurring Dengue
Cancer Epigenomics: Whole Genome Metylation Analysis of Breast and Colorectal Cancer
Whole Genome Sequencing of the Extremophiles Leucospodorium sp. And Bacillus G1
Systems Biology of a Psychrophilic Yearst for Novel Biotechnology
Designer Biocatalysts for Sustainable Processes in the Conversion of Renewable Raw Materials to Platform Chemicals
Space Crystalisation of Industrial Enzymes onboard The Japanese Experimental Module (JEM)
Application of novel matrix attachment region (MAR) elements for the development of high expression system in mammalian cells for production of complex recombinant proteins
Design and Development of Microbial Cell Factories for Biomolecules Production and Secretion
Robust Recombinant Carbohydrate-Acting Enzymes for Biomass Utilization
Analysis of Boesenbergia rotunda whole genome and selected transcriptome for identification of metabolic engineering targets
The Malaysian Cohort (9th MP and 10th MP)
This programme aims to improve health and well-being of Malaysians through predictive medicine. The project components includes:
- The recruitment of a population cohort of 100,000 individuals involving collection of high quality biospecimens and information on lifestyle.
- Research programme for discovery of biomarkers for various diseases including cancers, diabetes, stroke, hypertension, ischaemic heart disease using genomics as well as gene-environment interaction studies
- International collaboration with The Asia Cohort Consortium, Public Population Project in Genomics (P3G), The University of Oxford and The Broad Institute.
Science Fund Projects (10th MP)
9 projects funded by MOSTI/MESTECC
High Throughput Screen of Synthetic and Small Molecules as Anti-Infectives
Post-genomic Discovery of Small Hypothetical Proteins from Bacillus lehensis G1 Alkaliphile
Identification of Novel Enzymes for Total Utilization of Biomass via Transcriptomics of Termite Digestome
Mining for robust extremozymes and unique secondary metabolites from an indigenous hyperthermopholic Geobacillus sp. through deep sequencing and computational approaches for industrial biotechnology applications.
Elucidating the Gaharu Resin and Other Biosynthetic Pathways Using Large-Scale Transcriptome and Metabolite Profiling Via Comparison of Infected and Uninfected Trees
Peptide Design and Synthesis Based on Enzyme Mimics for Industrial Needs
Genome Based Robust Enzymes Discovery For Industrial Applications: Proteomics Identification of Secreted Enzymes from Bacillus lehensis G1
Comparative Genomics of Clinical and Environment Burkholderia Pseudomallei to understand emergence of virulence.
Structural and Functional Genomics of Glyeoside and Peptide Hydrolases from the extramophiles Glaciozyma antarctica and Bacillus lehensis G1 for the Biobased Economy.
International Collaboration / Research Project
Dissecting the Host-Pathogen Enigma: The Case for Burkholderiapseudomallei
Stanford University (Tan Man Wah)
Structural Genomics of the Extremophilic Microbes Leucosporidium antarticum and Bacillus lehensis G1
Monash University (Jamie Rossjohn)
Structural Genomics of Burkholderia pseudomallei Essential Genes
University of Sheffield (David Rice).
New Technologies for Sustainable Bio-Economy: Construction of Microbiol Cell BioCatalyst for Production of Biobased Fine Chemicals
Concordia University, Montreal, Canada
DSTIN FLAGSHIP Program/ Pre-Commercialisation Projects (10th MP)
New Technologies for sustainable Bio-Economy : Construction of microbiol Cell Biocatalyst for Production of Biobased Fine Chemicals.
Enhancing The therapeutic potential of rAF Newcastle Disease Virus Cancer Vaccine.
MOSTI SOCIAL INNOVATION (MSI)
Penentuan Profil Metabolite Madu Kelulut
Teknologi DNA & GPS Terhadap Koloni Kelulut
FUNDAMENTAL RESEARCH GRANT SCHEME (FRGS)
Identifying the Novel Features of Diacylglyceryl Transferase (LGT) Membrane Enzyme in Leptospirosis – causing bacteria
Elucidation Of Crystal Structure And Function Of Enzymes With Phenol
Removing Activity From Geobacillus.
RapidRAW Screening Technology: Fake Honey Detection
SEEDFUND MGI /INTERNAL
Recombinant production and characterization of potential feed enzymes from thermophile Geobacillus G5
Increasing recombinant phytase production through engineering Pichia pastoris secretion system
Development of single cell protein as a potential amino acid supplement for animal feed
Web-based Bioinformatics Data Analysis Pipeline
Reconstruction Of Prebiotic Producer Enzyme In Safer Organism (GRAS-Basis For U.S Regulatory Compliance)
Development of Genomic Profiling Pipeline for DNAku
Development of antibody conjugate for lateral flow assay for clenbuterol detection in food product
Production of biocompost and biogas from food waste
Identification of local isolated microbes for potential application in nutrition and biotechnology
Local Research Collaboration
Genome Sequencing of local isolates bacteria Lysinibacillus sp. and Enterobacter sp.
Analisis Mikrobiom yang Terlibat dalam Patogenesis Ganoderma Boninense Terhadap Pereputan Pangkal Batang Pokok Kelapa Sawit, Elaeis guineensis
Molecular Characterization of Familial Hypercholesterolemia (FH) in a Malay Population via Exome Sequencing
Proteomics Footprinting of Tecotrienols-treated Human Breast Cancer Cells.
Genomic Diversity of Malaysian Aborigine (Orang Asli).
Genome and transcriptome analyses of four Burkholderia pseudomallei isolated from Malaysia
Genome Sequencing and Analysis of Rhodococcus sp.
Comparative Genome Analyses and Phylogenomics Studies of Land and Marine Iguanas from the Galapagos Island
Functional characterization of hypothetical protein from Burkholderia pseudomallei
Structural Elucidation of Human APOBEC3B, a Cytosine Deaminase implicated in Cancer
Elucidation of the Neuro – Regenerative Signaling Pathway in Diopatra Claparedii
Unraveling the enzymes involved in dimerization of resveratrol.
Pemuliharaan Genetik Kelip-kelip Pteroptyx tener (Coleoptera: Lampyridae) di Kuala Selangor
Generation and Characterization of The Rafflesia Genome Sequence
Soil microbiome analysis of oil palm for potential Basal Stem Rot disease control
Comparative Genomics Of Rafflesia
Highland Stingless Bee Identification And The Assessment Of Domesticated Stingless Bee At High Altitude
Functional Studies of Mating Pheromones in Oil Palm Pathogen, Ganoderma boninense to Elucidate Its Pathogenicity
Targeted genomic Profile of Malay B-Thalassemia Patients by Using NGS
Penghasilan Madu Premium Berasaskan Inovasi Mustafa-Hive dan Hilda-Sistem
Determination of Molecular Characteristics and Cytotoxicity of Polyphenol from Aquilaria sp. (Gaharu) as Lipase Inhibitor in Obesity Treatment
Visualization model of biocatalysis remediation by polycyclic aromatic hydrocarbons-degrading enzymes through functional and structural characterization
Elucidation of structure and function of conserved hypothetical proteins related to thermal stress
response in psychrophilic bacterium and yeast
Mangosteen research sustainability using multi-omics integration and database development
Projek FRGS-MRSA: Characterisation of nanporous biochar-derived adsorbents from tropical biomass
Insights into the evolution of fiddler crab through whole genome comparison between Uca rosea with Uca annulipes
Role of recombinant protease derived from Malaysian belacan on eschar and biofilm removal for
necrotic wound healing
Cell Permeability and Biovailabity Evaluation of Citropten and its Anti-Inflammatory Properties in a Rat Model Inflammation
Oral pharmacokinetic evaluation of freeze-dried Carica papaya leaves juice formulations in rats
The Possible Use of Mitochondria as Indicator in Production Yield and Abnormality of Oil Palm
Traceability and Authenticity of Honey and Kelulut Honey
Skim Sequencing Of 96 Heterotrigona Itama Genome
(Illumina Award 2017 by Science Vision)